Dawn of the death of a technology….

Microarrays have fascinated me due to their highly parallel and miniaturized approach and the time, money and labour it saves during analyses. Microarrays have had many research applications including gene expression analysis and typing specific sequence variations in the human genome. But an interesting report in nature published 4 years before, says microarray could be a dying technology.

With the advent of novel sequencing technologies, faster, more reliable and cost effective sequences could be obtained in a fraction of the time compared to traditional sequencing methodologies. Thus researchers prefer to sequencing in some specific areas of life sciences research where microarrays have dominated. For example, certain limitations of microarray technology in analysis of genetic links to diseases has turned heads towards the targeted sequencing of certain regions of the genome rather than whole genome typing.

Several microarray companies are experiencing decline which some analysts think may be due to preference of sequencing in gene expression analysis over microarrays. Thus microarray manufacturers are focusing on more improved and cost effective designs which may provide better survival of this technology. And also creation of arrays known as ”capture arrays’ that specifically isolate targeted locations of the genome for sequencing have opened up new application of microarray technology. This joint venture of sequencing and array is more economical and enables effective utilization of resources.

Source : http://www.nature.com/news/2008/081015/full/455847a.html